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In the more recent study, the authors compared a high-dose colchicine regimen to a low-dose regimen.
In this study we have investigated the role of colchicine therapy in primary amyloidosis, and dimethylsulphoxide dmso in leprosy associated secondary amyloidosis.
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When allopurinol is initiated, maintenance colchicine doses should generally be administered as prophylaxis.
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However, these results should not be extrapolated to other p-gp inhibitors as colchicine is known to be a substrate for p-gp and case reports of colchicine toxicity associated with the co-administration of p-gp inhibitors such as cyclosporine have been published.
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